Artikelnummer: 300325

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Human Urinary bladder carcinoma cell line RT-112-D21

Organism: Homo sapiens (human)
Ethnicity: Caucasian
Tissue: Urinary bladder carcinoma
Morphology: Epithelial
Growth Properties: Monolayer, adherent
Description: This cell line is a Doxorubicin-resistant sub-clone of the parental cell line RT-112. Resistance was achieved by continuous exposure of the parental line RT-112 to increasing concentrations of doxorubicin over a period of 9 months. RT-112-D21 cells were 96 times more resistant to doxorubicin than RT-112 cells, and cross-resistance to epirubicin and vinblastine was present.
Karyotyping: DNA-index=2.1
Marker expression: Cytokeratine (4),5,(6), 7, 8, 13, 17, 18, 19, Desmoplakin